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Version: 17.06d (Release date: 2017-06-26)
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PARP Inhibitor CEP-9722 (Code C84880)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PARP Inhibitor CEP-9722

Definition: A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA.

Display Name: PARP Inhibitor CEP-9722

Label: PARP Inhibitor CEP-9722

NCI Thesaurus Code: C84880 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2827554  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CEP-9722
PARP Inhibitor CEP-9722

External Source Codes: 
PDQ Closed Trial Search ID 649505
PDQ Open Trial Search ID 649505 (check for NCI PDQ open clinical trial info)
UMLS CUI C2827554

Other Properties:
     Name Value (qualifiers indented underneath)
code C84880
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84880

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