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Version: 17.06d (Release date: 2017-06-26)
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Phospholipid Ether-drug Conjugate CLR 131 (Code C84879)

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Terms & Properties

Preferred Name: Phospholipid Ether-drug Conjugate CLR 131

Definition: A radiopharmaceutical composed of a mixture of proprietary phospholipid ethers (CLR 1404) that are covalently linked to the cytotoxic radioisotope iodine I 131 (iodine-131), with potential antineoplastic activity. Upon administration of CLR 131, the phospholipid ether (PLE) moiety is selectively taken up by lipid raft microdomains expressed on tumor cells and accumulates in the cytoplasm of tumor cells;. CLR 131 is not taken up by normal, healthy cells. This delivers cytotoxic iodine I 131 directly to and induces cell death in tumor cells. PLEs allows for targeted delivery of the radioisotope.

Display Name: Phospholipid Ether-drug Conjugate CLR 131

Label: Phospholipid Ether-drug Conjugate CLR 131

NCI Thesaurus Code: C84879 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412381  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[131I]-CLR1404
CLR 131
CLR 1404 I-131
I-131-CLR1404
I-131 PLE Analogue CLR1404
PDC CLR 131
Phospholipid Ether-drug Conjugate CLR 131

External Source Codes: 
PDQ Closed Trial Search ID 649140
PDQ Open Trial Search ID 649140 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412381

Other Properties:
     Name Value (qualifiers indented underneath)
code C84879
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84879

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