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Version: 17.06d (Release date: 2017-06-26)
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Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex (Code C84878)

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Terms & Properties

Preferred Name: Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex

Definition: A propylene glycol-free intravenous formulation containing the hydrochloride salt of the nitrogen mustard phenylalanine derivative melphalan complexed with polyanionic sulfobutyl ether beta-cyclodextrin (SBE-CD) with potential antineoplastic activity. Upon administration, melphalan is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA; RNA and proteins may also be alkylated. Subsequently, RNA transcription and protein synthesis are inhibited, resulting in cell growth arrest. The addition of sulfobutyl ether beta-cyclodextrin to the formulation improves the solubility, stability and ease of use of melphalan; cyclodextrins are cyclic dextrins derived from starch.

Display Name: Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex

Label: Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex

NCI Thesaurus Code: C84878 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412380  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Captisol-enabled Melphalan IV
Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex

External Source Codes: 
PDQ Closed Trial Search ID 649061
PDQ Open Trial Search ID 649061 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412380

Other Properties:
     Name Value (qualifiers indented underneath)
code C84878
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84878

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