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Version: 17.08d (Release date: 2017-08-28)
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Progesterone Vaginal Insert (Code C84874)

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Terms & Properties

Preferred Name: Progesterone Vaginal Insert

Definition: A tablet preparation formulated for vaginal administration containing a micronized synthetic form of the endogenous steroid hormone progesterone with progesterone activity. Upon vaginal insertion, progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogen by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy.

Label: Progesterone Vaginal Insert

NCI Thesaurus Code: C84874 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1961966  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Progesterone Vaginal Insert

External Source Codes: 
PDQ Closed Trial Search ID 648749
PDQ Open Trial Search ID 648749 (check for NCI PDQ open clinical trial info)
UMLS CUI C1961966

Other Properties:
     Name Value (qualifiers indented underneath)
code C84874
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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