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Version: 17.06d (Release date: 2017-06-26)
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IGF-1R/IR Inhibitor KW-2450 (Code C84871)

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Terms & Properties

Preferred Name: IGF-1R/IR Inhibitor KW-2450

Definition: An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.

Display Name: IGF-1R/IR Inhibitor KW-2450

Label: IGF-1R/IR Inhibitor KW-2450

NCI Thesaurus Code: C84871 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412997  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IGF-1R/IR Inhibitor KW-2450
KW-2450

External Source Codes: 
PDQ Closed Trial Search ID 648543
PDQ Open Trial Search ID 648543 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412997

Other Properties:
     Name Value (qualifiers indented underneath)
code C84871
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84871

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