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Version: 17.08d (Release date: 2017-08-28)
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Akt Inhibitor GSK2141795 (Code C84870)

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Terms & Properties

Preferred Name: Akt Inhibitor GSK2141795

Definition: An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Display Name: Akt Inhibitor GSK2141795

Label: Akt Inhibitor GSK2141795

NCI Thesaurus Code: C84870 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830127  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Akt Inhibitor GSK2141795
Oral Akt Inhibitor GSK2141795

External Source Codes: 
PDQ Closed Trial Search ID 648336
PDQ Open Trial Search ID 648336 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830127

Other Properties:
     Name Value (qualifiers indented underneath)
code C84870
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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