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Version: 17.06d (Release date: 2017-06-26)
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Ghrelin Peptide Analogue (Code C84868)

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Terms & Properties

Preferred Name: Ghrelin Peptide Analogue

Definition: A ghrelin peptide analogue with potential anti-cachexia activity. Upon subcutaneous administration, ghrelin peptide analogue binds to and stimulates the G protein-coupled growth hormone secretagogue receptor (GHSR) in the central nervous system (CNS), thereby mimicking the appetite-stimulating and growth hormone-releasing effects of endogenous ghrelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play direct roles in cancer-related loss of appetite. Ghrelin, naturally secreted by gastric endocrine cells, is a 28 amino acid peptide and an endogenous ligand for GHSR.

Label: Ghrelin Peptide Analogue

NCI Thesaurus Code: C84868 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412389  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ghrelin Peptide Analogue

External Source Codes: 
PDQ Closed Trial Search ID 650024
PDQ Open Trial Search ID 650024 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C84868
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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