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Version: 17.06d (Release date: 2017-06-26)
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Galeterone (Code C84866)

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Terms & Properties

Preferred Name: Galeterone

Definition: An orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.

Display Name: Galeterone

Label: Galeterone

NCI Thesaurus Code: C84866 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830126  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Androsta-5,16-dien-3-ol, 17-(1h-benzimidazol-1-yl)-, (3beta)-
Galeterone
GALETERONE
Specific Androgen Receptor Modulator/CYP17 Lyase Inhibitor TOK-001
TOK-001
VN/124
VN/124-1

External Source Codes: 
CAS Registry Number 851983-85-2 (see NLM ChemIDplus info)
FDA UNII Code WA33E149SW
PDQ Closed Trial Search ID 653977
PDQ Open Trial Search ID 653977 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830126

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H32N2O
code C84866
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84866

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