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National Cancer Institute
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Version: 16.11d (Release date: 2016-11-28)
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Binimetinib (Code C84865)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Binimetinib

Definition: An orally available inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2) with potential antineoplastic activity. Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.

Display Name: Binimetinib

Label: Binimetinib

NCI Thesaurus Code: C84865 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830125  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARRY-162
ARRY-438162
Binimetinib
MEK162

External Source Codes: 
PDQ Closed Trial Search ID 653635
PDQ Open Trial Search ID 653635 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830125

Other Properties:
Name Value (qualifiers indented underneath)
code C84865
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84865

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