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Version: 17.06d (Release date: 2017-06-26)
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Pimasertib (Code C84864)

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Terms & Properties

Preferred Name: Pimasertib

Definition: An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.

Display Name: Pimasertib

Label: Pimasertib

NCI Thesaurus Code: C84864 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830124  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AS703026
EMD 1036239
MSC1936369
N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4- iodophenyl)amino]isonicotinamide Hydrochloride
Pimasertib
PIMASERTIB

External Source Codes: 
CAS Registry Number 1236699-92-5 (see NLM ChemIDplus info)
FDA UNII Code 6ON9RK82AL
PDQ Closed Trial Search ID 653634
PDQ Open Trial Search ID 653634 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830124

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H15FIN3O3
code C84864
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84864

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