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Version: 17.12d (Release date: 2017-12-26)
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Pimasertib (Code C84864)

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Terms & Properties

Preferred Name: Pimasertib

Definition: An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.

Display Name: Pimasertib

Label: Pimasertib

NCI Thesaurus Code: C84864 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830124  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EMD 1036239
N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4- iodophenyl)amino]isonicotinamide Hydrochloride

External Source Codes: 
CAS Registry Number 1236699-92-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 653634
PDQ Open Trial Search ID 653634 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830124

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H15FIN3O3
code C84864
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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