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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Menadione Topical Lotion (Code C84863)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Menadione Topical Lotion

Definition: A topical lotion containing the small organic molecule protein tyrosine phosphatase (PTP) inhibitor menadione (vitamin K3) with potential EGFR- and ErbB2/HER2-activating activities. Upon topical administration, menadione binds to and inhibits the activity of PTPs that dephosphorylate and inactivate EGFR and ErbB2 in human keratinocytes; local reversal of EGFR and ErbB2 inhibition associated with the systemic administration of EGFR inhibitors may help alleviate EGFR inhibitor-mediated skin toxicity. EGFR (epidermal growth factor receptor) and ErbB2/HER2 (erythroblastic leukemia viral oncogene homolog 2/ human epidermal growth factor receptor 2) are cell surface receptors that are upregulated in a number of cancer cells types and play important roles in the growth and maintenance of normal epithelial tissues.

Display Name: Menadione Topical Lotion

Label: Menadione Topical Lotion

NCI Thesaurus Code: C84863 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412424  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Menadione Topical Lotion

External Source Codes: 
PDQ Closed Trial Search ID 652615
PDQ Open Trial Search ID 652615 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C84863
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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