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Version: 16.11d (Release date: 2016-11-28)
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Hedgehog Inhibitor PF-04449913 (Code C84862)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hedgehog Inhibitor PF-04449913

Definition: An orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Hedgehog inhibitor PF-04449913 appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies.

Display Name: Hedgehog Inhibitor PF-04449913

Label: Hedgehog Inhibitor PF-04449913

NCI Thesaurus Code: C84862 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412426  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hedgehog Inhibitor PF-04449913

External Source Codes: 
PDQ Closed Trial Search ID 652940
PDQ Open Trial Search ID 652940 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412426

Other Properties:
Name Value (qualifiers indented underneath)
code C84862
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84862

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