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National Cancer Institute
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Version: 17.08d (Release date: 2017-08-28)
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Membrane-Disrupting Peptide EP-100 (Code C84860)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Membrane-Disrupting Peptide EP-100

Definition: A water-soluble, positively charged fusion protein consisting of a luteinizing hormone releasing hormone (LHRH) receptor-targeting ligand conjugated to the membrane-disrupting peptide CLIP 71 with membrane-disrupting and potential antineoplastic activities. The LHRH ligand moiety of membrane-disrupting peptide EP-100 specifically binds to LHRH receptors, which are upregulated on a variety of human cancer cell types. Subsequently, the positively charged CLIP 71 moiety of this agent interacts with the negatively charged membrane on the cancer cell surface, which may result in cell membrane disruption and cell lysis.

Display Name: Membrane-Disrupting Peptide EP-100

Label: Membrane-Disrupting Peptide EP-100

NCI Thesaurus Code: C84860 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412421  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Membrane-Disrupting Peptide EP-100

External Source Codes: 
PDQ Closed Trial Search ID 652192
PDQ Open Trial Search ID 652192 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C84860
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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