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Version: 17.06d (Release date: 2017-06-26)
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DEC-205/NY-ESO-1 Fusion Protein CDX-1401 (Code C84859)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: DEC-205/NY-ESO-1 Fusion Protein CDX-1401

Definition: A fusion protein consisting of a fully human monoclonal antibody directed against the endocytic dendritic cell (DC) receptor, DEC-205, linked to the tumor-associated antigen (TAA) NY-ESO-1 with potential immunostimulating and antineoplastic activities. The monoclonal antibody moiety of DEC-205/NY-ESO-1 fusion protein CDX-1401 binds to the endocytic DC receptor, which may result in DC endocytic internalization of this agent, specifically delivering the NY-ESO-1 moiety. DC processing of NY-ESO-1 may boost the immune system to mount a cytotoxic T-lymphocyte response (CTL) against cancer cells expressing NY-ESO-1. NY-ESO-1, a cell surface protein expressed in normal fetal and adult testes, is upregulated in a variety of tumor cell types.

Display Name: DEC-205/NY-ESO-1 Fusion Protein CDX-1401

Label: DEC-205/NY-ESO-1 Fusion Protein CDX-1401

NCI Thesaurus Code: C84859 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412417  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CDX-1401
DEC-205/NY-ESO-1 Fusion Protein CDX-1401

External Source Codes: 
PDQ Closed Trial Search ID 651880
PDQ Open Trial Search ID 651880 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412417

Other Properties:
     Name Value (qualifiers indented underneath)
code C84859
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84859

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