skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
MEK Inhibitor TAK-733 (Code C84858)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: MEK Inhibitor TAK-733

Definition: An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.

Display Name: MEK Inhibitor TAK-733

Label: MEK Inhibitor TAK-733

NCI Thesaurus Code: C84858 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2827535  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MEK Inhibitor TAK-733
TAK-733

External Source Codes: 
PDQ Closed Trial Search ID 651550
PDQ Open Trial Search ID 651550 (check for NCI PDQ open clinical trial info)
UMLS CUI C2827535

Other Properties:
     Name Value (qualifiers indented underneath)
code C84858
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84858

Mainbox Bottom