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Version: 17.06d (Release date: 2017-06-26)
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16,16-Dimethyl Prostaglandin E2 (Code C84850)

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Terms & Properties

Preferred Name: 16,16-Dimethyl Prostaglandin E2

Definition: A stable derivative of prostaglandin E2 (PGE2) with potential hematopoietic activity. Administration of 16,16 dimethyl-prostaglandin E2 (dmPGE2) appears to lead to increased formation of hematopoietic stem and progenitor cells. Even though the exact mechanism of action has yet to be fully elucidated, this agent may stimulate hematopoiesis by activating the Wnt signaling pathway, which increases cellular levels of beta-catenin, a subunit of the cadherin protein complex.

Display Name: 16,16-Dimethyl Prostaglandin E2

Label: 16,16-Dimethyl Prostaglandin E2

NCI Thesaurus Code: C84850 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412404  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
16,16-Dimethyl Prostaglandin E2
dmPGE2

External Source Codes: 
PDQ Closed Trial Search ID 651165
PDQ Open Trial Search ID 651165 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412404

Other Properties:
     Name Value (qualifiers indented underneath)
code C84850
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84850

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