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Version: 16.11d (Release date: 2016-11-28)
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HLA-A*0201-Restricted TRP2-gp100-EphA2-HER2 multipeptide Vaccine (Code C84844)

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Terms & Properties

Preferred Name: HLA-A*0201-Restricted TRP2-gp100-EphA2-HER2 multipeptide Vaccine

Definition: A cancer vaccine containing four HLA-A*0201-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Vaccine peptide epitopes are derived from the tumor associated antigens (TAAs) tyrosinase-related protein 2 (TRP2), glycoprotein 100 (gp100), Ephrin receptor A2 (EphA2) and human epidermal growth factor receptor 2 (HER2). Upon administration, HLA-A*0201-restricted TRp2-gp100-EphA2-HER2 multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against TRP2-gp100-EphA2-HER2-expressing tumor cells, resulting in tumor cell lysis and decreased tumor cell proliferation. HLA-A*0201 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*0201 may improve antigenic peptide immunogenicity.

Display Name: HLA-A*0201-restricted TRP2-gp100-EphA2-HER2 multipeptide Vaccine

Label: HLA-A*0201-Restricted TRP2-gp100-EphA2-HER2 multipeptide Vaccine

NCI Thesaurus Code: C84844 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412397  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HLA-A*0201-restricted TRP2-gp100-EphA2-HER2 multipeptide Vaccine
HLA-A*0201-Restricted TRP2-gp100-EphA2-HER2 multipeptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 650427
PDQ Open Trial Search ID 650427 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412397

Other Properties:
Name Value (qualifiers indented underneath)
code C84844
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84844

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