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National Cancer Institute
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Version: 17.08d (Release date: 2017-08-28)
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PAK4 Inhibitor PF-03758309 (Code C84841)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PAK4 Inhibitor PF-03758309

Definition: An orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.

Display Name: PAK4 Inhibitor PF-03758309

Label: PAK4 Inhibitor PF-03758309

NCI Thesaurus Code: C84841 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412392  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PAK4 Inhibitor PF-03758309

External Source Codes: 
PDQ Closed Trial Search ID 650124
PDQ Open Trial Search ID 650124 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C84841
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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