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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Oncolytic HSV1716 (Code C84840)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oncolytic HSV1716

Definition: A neuroattenuated, replication-restricted, ICP34.5 deleted (RL1 gene)-mutant herpes simplex virus (HSV) type I, constructed from wild-type strain 17, with potential oncolytic activity. Upon intratumoral injection, oncolytic HSV1716 transfects, replicates in, and lyses rapidly dividing cells such as tumor cells. Because the RL1 gene is deleted, HSV1716 is unable to replicate in non-dividing cells.

Display Name: Oncolytic HSV1716

Label: Oncolytic HSV1716

NCI Thesaurus Code: C84840 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412391  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oncolytic HSV1716

External Source Codes: 
PDQ Closed Trial Search ID 650036
PDQ Open Trial Search ID 650036 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C84840
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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