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Version: 17.06d (Release date: 2017-06-26)
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Fulranumab (Code C84838)

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Terms & Properties

Preferred Name: Fulranumab

Definition: A fully human monoclonal antibody directed against nerve growth factor (NGF) with potential analgesic activity. Upon administration, fulranumab binds to NGF, preventing its binding to and activation of the NGF receptors TrkA and p75NTR. Inhibition of the NGF pathway may prevent the perception of pain and may induce analgesia. NGF, a neurotrophic factor that plays a key role in neuropathic and inflammatory-induced pain, promotes hyperalgesia and allodynia.

Display Name: Fulranumab

Label: Fulranumab

NCI Thesaurus Code: C84838 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981231  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG 403
Anti-NGF Monoclonal Antibody JNJ-42160443
Fulranumab
FULRANUMAB
JNJ-42160443

External Source Codes: 
CAS Registry Number 902141-80-4 (see NLM ChemIDplus info)
FDA UNII Code 0E986JU40I
PDQ Closed Trial Search ID 649764
PDQ Open Trial Search ID 649764 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981231

Other Properties:
     Name Value (qualifiers indented underneath)
code C84838
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84838

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