skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
PI3K/mTOR Kinase Inhibitor PF-04691502 (Code C84837)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PI3K/mTOR Kinase Inhibitor PF-04691502

Definition: An agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PF-04691502 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.

Display Name: PI3K/mTOR Kinase Inhibitor PF-04691502

Label: PI3K/mTOR Kinase Inhibitor PF-04691502

NCI Thesaurus Code: C84837 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2827515  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PF-04691502
PI3K/mTOR Kinase Inhibitor PF-04691502

External Source Codes: 
PDQ Closed Trial Search ID 649523
PDQ Open Trial Search ID 649523 (check for NCI PDQ open clinical trial info)
UMLS CUI C2827515

Other Properties:
     Name Value (qualifiers indented underneath)
code C84837
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84837

Mainbox Bottom