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Version: 17.06d (Release date: 2017-06-26)
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PI3K/mTOR Kinase Inhibitor PF-04691502 (Code C84837)

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Terms & Properties

Preferred Name: PI3K/mTOR Kinase Inhibitor PF-04691502

Definition: An agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PF-04691502 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.

Display Name: PI3K/mTOR Kinase Inhibitor PF-04691502

Label: PI3K/mTOR Kinase Inhibitor PF-04691502

NCI Thesaurus Code: C84837 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2827515  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PI3K/mTOR Kinase Inhibitor PF-04691502

External Source Codes: 
PDQ Closed Trial Search ID 649523
PDQ Open Trial Search ID 649523 (check for NCI PDQ open clinical trial info)
UMLS CUI C2827515

Other Properties:
     Name Value (qualifiers indented underneath)
code C84837
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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