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Version: 17.06d (Release date: 2017-06-26)
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Hsp90 Inhibitor MPC-3100 (Code C84836)

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Terms & Properties

Preferred Name: Hsp90 Inhibitor MPC-3100

Definition: An orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor MPC-3100 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this agent may inhibit the growth and survival of a wide variety of cancer cell types. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability, and degradation of many oncogenic signaling proteins.

Label: Hsp90 Inhibitor MPC-3100

NCI Thesaurus Code: C84836 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830123  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hsp90 Inhibitor MPC-3100
MPC-3100

External Source Codes: 
PDQ Closed Trial Search ID 649142
PDQ Open Trial Search ID 649142 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830123

Other Properties:
     Name Value (qualifiers indented underneath)
code C84836
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84836

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