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Version: 17.06d (Release date: 2017-06-26)
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hTERT/Survivin/Melanoma Tumor Cell-Derived mRNA-Transfected Dendritic Cell Vaccine (Code C84755)

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Terms & Properties

Preferred Name: hTERT/Survivin/Melanoma Tumor Cell-Derived mRNA-Transfected Dendritic Cell Vaccine

Definition: A cancer vaccine containing dendritic cells (DCs) that are transfected with messenger RNA (mRNA) encoding human telomerase reverse transcriptase (hTERT) and survivin in addition to patient-specific melanoma-derived mRNA with potential immunostimulatory and antineoplastic activities. Upon administration, hTERT/survivin/melanoma tumor cell-derived mRNA-transfected dendritic cell vaccine may elicit a highly specific cytotoxic T-cell (CTL) response against melanoma cells expressing hTERT, survivin, and patient-specific melanoma-associated antigens. hTERT, the catalytic subunit of human telomerase, and survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, may be upregulated in certain tumor cell types, playing key roles in tumor cell growth and survival.

Label: hTERT/Survivin/Melanoma Tumor Cell-Derived mRNA-Transfected Dendritic Cell Vaccine

NCI Thesaurus Code: C84755 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412432  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
hTERT/Survivin/Melanoma Tumor Cell-Derived mRNA-Transfected Dendritic Cell Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 653980
PDQ Open Trial Search ID 653980 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412432

Other Properties:
     Name Value (qualifiers indented underneath)
code C84755
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84755

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