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Version: 16.11d (Release date: 2016-11-28)
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Streptozocin (Code C845)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Streptozocin

Definition: A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called alkylating agents.

Label: Streptozocin

NCI Thesaurus Code: C845 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0038432  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose
STREPTOZOCIN
Streptozocin
streptozocin
Streptozotocin
STZ
U-9889
U 9889
Zanosar

External Source Codes: 
CAS Registry Number 18883-66-4 (see NLM ChemIDplus info)
FDA UNII Code 5W494URQ81
ChEBI ID CHEBI:9288 (see ChEBI info)
NSC Code 85998 (see NCI DTP info)
PDQ Closed Trial Search ID 42831
PDQ Open Trial Search ID 42831 (check for NCI PDQ open clinical trial info)
UMLS CUI C0038432

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Carcinoid tumor and syndrome; Colorectal cancer, palliative; Hodgkin's disease; Metastatic islet cell carcinoma of the pancreas
Chemical_Formula C8H15N3O7
code C845
Contributing_Source FDA
Legacy_Concept_Name Streptozocin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C845

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