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Version: 16.11d (Release date: 2016-11-28)
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Streptonigrin (Code C844)

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Terms & Properties

Preferred Name: Streptonigrin

Definition: An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04)

Label: Streptonigrin

NCI Thesaurus Code: C844 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0038427  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid
5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid
BA-163
Bruneomycin
PC-501
Rufocromomycin
STN
STREPTONIGRIN
Streptonigrin

External Source Codes: 
CAS Registry Number 3930-19-6 (see NLM ChemIDplus info)
FDA UNII Code 261Q3JB310
ChEBI ID CHEBI:9287 (see ChEBI info)
NSC Code 45383 (see NCI DTP info)
NSC Code 83950 (see NCI DTP info)
PDQ Closed Trial Search ID 39703
PDQ Open Trial Search ID 39703 (check for NCI PDQ open clinical trial info)
UMLS CUI C0038427

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C25H22N4O8
code C844
Contributing_Source FDA
Legacy_Concept_Name Streptonigrin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C844

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