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Version: 17.06d (Release date: 2017-06-26)
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Ustekinumab (Code C84237)

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Terms & Properties

Preferred Name: Ustekinumab

Definition: An orally available, human, IgG1kappa, monoclonal antibody directed against the p40 protein subunit of both interleukin-12 (IL-12) and IL-23, with immunomodulating activity. Upon administration, ustekinumab binds to the p40 subunit of IL-12 and IL-23, blocking the binding of IL-12 and IL-23 to their interleukin receptors. This inhibits IL-12- and IL-23-mediated signaling and inhibits differentiation of CD4 positive T-cells into Th1 and Th17 cells. This prevents Th1- and Th17-mediated responses and cytokine production. This may prevent graft versus host disease (GVHD). IL-12 and IL-23, cytokines that play a key role in the regulation of the immune system, are upregulated in immune-mediated inflammatory disorders. Both Th1 and Th17 cells play a crucial role in GVHD.

Display Name: Ustekinumab

Label: Ustekinumab

NCI Thesaurus Code: C84237 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1608841  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CNTO1275
CNTO 1275
Immunoglobulin G1, Anti-(Human Interleukin-12 Subunit beta (IL-12B, CLMF p40, NKSF2)) (Human Monoclonal CNTO 1275 gamma1-chain), Disulfide with Human Monoclonal CNTO 1275 kappa-chain, Dimer
Stelara
Ustekinumab
USTEKINUMAB

External Source Codes: 
CAS Registry Number 815610-63-0 (see NLM ChemIDplus info)
FDA UNII Code FU77B4U5Z0
PDQ Closed Trial Search ID 747205
PDQ Open Trial Search ID 747205 (check for NCI PDQ open clinical trial info)
UMLS CUI C1608841

Other Properties:
     Name Value (qualifiers indented underneath)
code C84237
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84237

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