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Version: 17.06d (Release date: 2017-06-26)
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Tocilizumab (Code C84217)

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Terms & Properties

Preferred Name: Tocilizumab

Definition: A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. Il-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders and certain types of cancers.

Display Name: Tocilizumab

Label: Tocilizumab

NCI Thesaurus Code: C84217 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1609165  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Actemra
Immunoglobulin G1, Anti-(Human Interleukin 6 Receptor) (Human-Mouse Monoclonal MRA Heavy Chain), Disulfide with Human-Mouse Monoclonal MRA Kappa-Chain, Dimer
MRA
R-1569
RoActemra
Tocilizumab
TOCILIZUMAB

External Source Codes: 
CAS Registry Number 375823-41-9 (see NLM ChemIDplus info)
FDA UNII Code I031V2H011
ChEBI ID CHEBI:64360 (see ChEBI info)
PDQ Closed Trial Search ID 713832
PDQ Open Trial Search ID 713832 (check for NCI PDQ open clinical trial info)
UMLS CUI C1609165

Other Properties:
     Name Value (qualifiers indented underneath)
code C84217
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C84217

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