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Version: 17.06d (Release date: 2017-06-26)
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Spironolactone (Code C840)

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Terms & Properties

Preferred Name: Spironolactone

Definition: A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors.

Display Name: Spironolactone

Label: Spironolactone

NCI Thesaurus Code: C840 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0037982  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate
SC 9420

External Source Codes: 
CAS Registry Number 52-01-7 (see NLM ChemIDplus info)
FDA UNII Code 27O7W4T232
ChEBI ID CHEBI:9241 (see ChEBI info)
NSC Code 150399 (see NCI DTP info)
PDQ Closed Trial Search ID 39444
PDQ Open Trial Search ID 39444 (check for NCI PDQ open clinical trial info)
UMLS CUI C0037982

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H32O4S
code C840
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Spironolactone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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