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Version: 17.06d (Release date: 2017-06-26)
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Lucanthone (Code C83925)

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Terms & Properties

Preferred Name: Lucanthone

Definition: An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity. Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, thereby inhibiting the synthesis of macromolecules. In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, resulting in un-repaired DNA strand breaks which may induce apoptosis. Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy through the disruption of lysosomal function. The multifunctional nuclease APE1 is a key component for DNA repair; its expression is often correlated with tumor cell resistance to radio- and chemotherapy.

Display Name: Lucanthone

Label: Lucanthone

NCI Thesaurus Code: C83925 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0024071  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Lucanthone
LUCANTHONE

External Source Codes: 
CAS Registry Number 479-50-5 (see NLM ChemIDplus info)
FDA UNII Code FC6D57000M
ChEBI ID CHEBI:51052 (see ChEBI info)
PDQ Closed Trial Search ID 733534
PDQ Open Trial Search ID 733534 (check for NCI PDQ open clinical trial info)
UMLS CUI C0024071

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H24N2OS
code C83925
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C83925

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