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Version: 17.06d (Release date: 2017-06-26)
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Lacosamide (Code C83859)

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Terms & Properties

Preferred Name: Lacosamide

Definition: A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.

Display Name: Lacosamide

Label: Lacosamide

NCI Thesaurus Code: C83859 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1311230  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADD 234037
SPM 927

External Source Codes: 
CAS Registry Number 175481-36-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 712043
PDQ Open Trial Search ID 712043 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 17395176 (see PubMed Primary Reference info)
UMLS CUI C1311230

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H18N2O3
code C83859
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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