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Version: 17.10e (Release date: 2017-10-30)
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Fosbretabulin Tromethamine (Code C83721)

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Terms & Properties

Preferred Name: Fosbretabulin Tromethamine

Definition: The tromethamine salt form of prodrug fosbretabulin, a water-soluble phosphate derivative of a stilbenoid phenol derived from the African bush willow (Combretum caffrum) with antineoplastic activities. Upon administration, fosbretabulin is dephosphorylated to its active metabolite, combretastatin A4, which targets and binds to tubulin dimers and prevents microtubule polymerization, thereby resulting in mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis.

Display Name: Fosbretabulin Tromethamine

Label: Fosbretabulin Tromethamine

NCI Thesaurus Code: C83721 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2827157  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3-Dihydroxy-2-(Hydroxymethyl)Propan-2-Aminium 2-Methoxy-5-((1z)-2-(3,4,5-Trimethoxyphenyl)Ethenyl)Phenyl Hydrogen Phosphate
1,3-Propanediol, 2-Amino-2-(Hydroxymethyl)-, Compd. With 2-Methoxy-5-((1z)-2-(3,4,5-Trimethoxyphenyl)Ethenyl)Phenyl Dihydrogen Phosphate (1:1)
Fosbretabulin Tromethamine

External Source Codes: 
CAS Registry Number 404886-32-4 (see NLM ChemIDplus info)
FDA UNII Code GBW044919E
PDQ Closed Trial Search ID 696306
PDQ Open Trial Search ID 696306 (check for NCI PDQ open clinical trial info)
UMLS CUI C2827157

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H21O8P.C4H11NO3
code C83721
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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