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Version: 16.11d (Release date: 2016-11-28)
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Semustine (Code C827)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Semustine

Definition: A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called alkylating agents.

Label: Semustine

NCI Thesaurus Code: C827 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0036637  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea
1-(2-Chloroethyl)-3-(trans-4-methylcyclohexane)-1-nitrosourea
Lomustine, Methyl
Lomustine, methyl
MCCNU
MeCCNU
methyl-CCNU
Methyl CCNU
Methyl Lomustine
SEMUSTINE
Semustine
semustine
trans-Methyl-CCNU
Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI)
urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI)
Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)
urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)

External Source Codes: 
CAS Registry Number 13909-09-6 (see NLM ChemIDplus info)
FDA UNII Code 6YY7T1T567
NSC Code 95441 (see NCI DTP info)
PDQ Closed Trial Search ID 43727
PDQ Open Trial Search ID 43727 (check for NCI PDQ open clinical trial info)
UMLS CUI C0036637

Other Properties:
Name Value (qualifiers indented underneath)
code C827
Contributing_Source FDA
Legacy_Concept_Name Semustine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C827

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