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Version: 16.11d (Release date: 2016-11-28)
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MEK Inhibitor RO4987655 (Code C82696)

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Terms & Properties

Preferred Name: MEK Inhibitor RO4987655

Definition: An orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK-dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

Label: MEK Inhibitor RO4987655

NCI Thesaurus Code: C82696 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388474  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MEK Inhibitor RO4987655
RO4987655

External Source Codes: 
PDQ Closed Trial Search ID 633506
PDQ Open Trial Search ID 633506 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388474

Other Properties:
Name Value (qualifiers indented underneath)
code C82696
Legacy_Concept_Name MEK_Serine_Threonine_Kinase_Inhibitor_RO4987655
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82696

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