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Version: 17.06d (Release date: 2017-06-26)
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Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621 (Code C82694)

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Terms & Properties

Preferred Name: Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621

Definition: A small-molecule inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor ARQ 621 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein involved in the regulation of spindle dynamics, including assembly and maintenance, during mitosis.

Label: Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621

NCI Thesaurus Code: C82694 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388484  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ARQ 621
Eg5 inhibitor ARQ 621
Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621

External Source Codes: 
PDQ Closed Trial Search ID 634612
PDQ Open Trial Search ID 634612 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C82694
Legacy_Concept_Name Eg5_Kinesin-Related_Motor_Protein_Inhibitor_ARQ_621
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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