skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Sheddase Inhibitor INCB007839 (Code C82692)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sheddase Inhibitor INCB007839

Definition: An orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Sheddase inhibitor INCB007839 represses the metalloproteinase ""sheddase"" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. The metalloproteinase domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the cell membrane, releasing or ""shedding"" soluble protein etcodomains from the cell surface; the disintegrin domains of these multifunctional proteins interact with various components of the extracellular matrix (ECM). ADAM10 processes particular epithelial growth factor receptor (EGFR) ligands and appears to regulate Notch signaling through the cleavage of Notch and its related ligand delta-like ligand-1 (Dll-1). ADAM17 (also known as Tumor necrosis factor-Converting Enzyme or TACE) is involved in processing tumor necrosis factor (TNF) from its membrane bound precursor to its soluble circulating form and in processing ligands for the epidermal growth factor receptor (EGFR) family.

Display Name: Sheddase Inhibitor INCB007839

Label: Sheddase Inhibitor INCB007839

NCI Thesaurus Code: C82692 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388480  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
INCB007839
Sheddase Inhibitor INCB007839

External Source Codes: 
PDQ Closed Trial Search ID 633945
PDQ Open Trial Search ID 633945 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388480

Other Properties:
     Name Value (qualifiers indented underneath)
code C82692
Contributing_Source CTRP
Legacy_Concept_Name Sheddase_Inhibitor_INCB007839
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82692

Mainbox Bottom