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Version: 16.10e (Release date: 2016-10-31)
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Hsp90 Inhibitor AB-010 (Code C82691)

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Terms & Properties

Preferred Name: Hsp90 Inhibitor AB-010

Definition: An orally bioavailable nanoparticle albumin-bound inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor AB-010 selectively binds to Hsp90, inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This agent may inhibit the growth of a wide variety of cancer cell types; the incorporation of albumin into its formulation may facilitate its endothelial transcytosis through the gp60-regulated albumin transport pathway. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding and degradation of many oncogenic signaling proteins.

Label: Hsp90 Inhibitor AB-010

NCI Thesaurus Code: C82691 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388478  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AB-010
Heat Shock Protein 90 Inhibitor AB-010
Hsp90 Inhibitor AB-010

External Source Codes: 
PDQ Closed Trial Search ID 633820
PDQ Open Trial Search ID 633820 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388478

Other Properties:
Name Value (qualifiers indented underneath)
code C82691
Legacy_Concept_Name Hsp90_Inhibitor_AB-010
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82691

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