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Version: 17.10e (Release date: 2017-10-30)
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Irinotecan-Eluting Beads (Code C82682)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Irinotecan-Eluting Beads

Definition: Microporous hydrospheres of polyvinylalcohol (PVA) impregnated with irinotecan with potential antineoplastic activity. In transarterial chemoembolization (TACE), irinotecan-eluting beads are administered into blood vessels that feed the tumor, occluding tumor blood vessels and inducing ischemic tumor necrosis while simultaneously delivering high-dose chemotherapy locally. Irinotecan, a semisynthetic derivative of camptothecin, inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.

Display Name: Irinotecan-Eluting Beads

Label: Irinotecan-Eluting Beads

NCI Thesaurus Code: C82682 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388467  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Irinotecan Hydrochloride Drug-eluting Beads
Irinotecan-Eluting Beads

External Source Codes: 
PDQ Closed Trial Search ID 632992
PDQ Open Trial Search ID 632992 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C82682
Contributing_Source CTRP
Legacy_Concept_Name Irinotecan-Eluting_Beads
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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