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Version: 17.06d (Release date: 2017-06-26)
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c-Met Inhibitor AMG 208 (Code C82677)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: c-Met Inhibitor AMG 208

Definition: A selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity, which may result in cell growth inhibition in tumors that overexpress c-Met. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers.

Display Name: c-Met Inhibitor AMG 208

Label: c-Met Inhibitor AMG 208

NCI Thesaurus Code: C82677 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388463  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG 208
c-Met Inhibitor AMG 208

External Source Codes: 
PDQ Closed Trial Search ID 632625
PDQ Open Trial Search ID 632625 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388463

Other Properties:
     Name Value (qualifiers indented underneath)
code C82677
Contributing_Source CTRP
Legacy_Concept_Name c-Met_Inhibitor_AMG_208
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82677

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