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Version: 17.12d (Release date: 2017-12-26)
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Liposomal Irinotecan (Code C82676)

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Terms & Properties

Preferred Name: Liposomal Irinotecan

Definition: A liposomal formulation of the hydrochloride salt of the semisynthetic camptothecin analogue irinotecan with potential antineoplastic activity. During the S phase of the cell cycle, irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell.

Display Name: Liposomal Irinotecan

Label: Liposomal Irinotecan

NCI Thesaurus Code: C82676 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C4057931  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Irinotecan Liposome
Liposomal Irinotecan
Nanoliposomal Irinotecan
Nanoparticle Liposome Formulation of Irinotecan

External Source Codes: 
PDQ Closed Trial Search ID 632436
PDQ Open Trial Search ID 632436 (check for NCI PDQ open clinical trial info)
UMLS CUI C4057931

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For metastatic adenocarcinoma of the pancreas
code C82676
Contributing_Source CTRP
Legacy_Concept_Name Liposome-Encapsulated_Irinotecan_Hydrochloride_PEP02
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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