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Version: 16.11d (Release date: 2016-11-28)
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Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride (Code C82660)

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Terms & Properties

Preferred Name: Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride

Definition: An enteric-coated orally bioavailable formulation of the hydrochloride salt of a small-molecule agonist for transient receptor potential melastatin member 8 (TRPM8 or Trp-p8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer.

Label: Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride

NCI Thesaurus Code: C82660 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL411370  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EC D-3263 HCl
Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 636649
PDQ Open Trial Search ID 636649 (check for NCI PDQ open clinical trial info)
NCI META CUI CL411370

Other Properties:
Name Value (qualifiers indented underneath)
code C82660
Legacy_Concept_Name Enteric-Coated_TRPM8_Agonist_D-3263_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82660

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