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Version: 17.06d (Release date: 2017-06-26)
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Pegylated Recombinant Human Hyaluronidase PH20 (Code C82659)

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Terms & Properties

Preferred Name: Pegylated Recombinant Human Hyaluronidase PH20

Definition: A pegylated formulation of a recombinant form of human hyaluronidase with potential antitumor activity. Upon intravenous administration, pegylated recombinant human PH20 degrades hyaluronic acid (HA) coating tumor cells, which may result in the inhibition of tumor cell growth. In addition, the degradation of HA may result in a lowering of the interstitial fluid pressure (IFP), allowing better penetration of chemotherapeutic agents into the tumor bed. HA is a glycosaminoglycan found in the extracellular matrix (ECM) that is frequently overproduced by various tumor cell types. The presence of HA in tumors correlates with increased tumor cell growth, metastatic potential, tumor progression, increased resistance to chemotherapeutic agents, and an elevation in tumor IFP.

Display Name: Pegylated Recombinant Human Hyaluronidase PH20

Label: Pegylated Recombinant Human Hyaluronidase PH20

NCI Thesaurus Code: C82659 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388491  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Pegylated Recombinant Human Hyaluronidase PH20
Pegylated Recombinant Human PH20
Pegylated rHuPH20

External Source Codes: 
PDQ Closed Trial Search ID 636196
PDQ Open Trial Search ID 636196 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C82659
Contributing_Source CTRP
Legacy_Concept_Name Pegylated_Recombinant_Human_Hyaluronidase_PH20
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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