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Version: 17.06d (Release date: 2017-06-26)
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Beta-Glucan MM-10-001 (Code C82657)

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Terms & Properties

Preferred Name: Beta-Glucan MM-10-001

Definition: A powder formulation containing a triple helix beta-glucan, isolated from the cell walls of the shiitake mushroom (Lentinula edodes), with potential immunostimulating activity. The beta-glucan in beta-glucan MM-10-001 binds to a lectin site within the complement receptor 3 (CR3 or iC3b receptor) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to iC3b-opsonized tumor cells. iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b.

Display Name: Beta-Glucan MM-10-001

Label: Beta-Glucan MM-10-001

NCI Thesaurus Code: C82657 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388490  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Beta-Glucan MM-10-001
MM-10-001

External Source Codes: 
PDQ Closed Trial Search ID 636186
PDQ Open Trial Search ID 636186 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388490

Other Properties:
     Name Value (qualifiers indented underneath)
code C82657
Contributing_Source CTRP
Legacy_Concept_Name Beta-Glucan_MM-10-001
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82657

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