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Version: 17.06d (Release date: 2017-06-26)
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Afamelanotide (Code C82655)

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Terms & Properties

Preferred Name: Afamelanotide

Definition: A synthetic peptide analogue of the naturally occurring alpha-melanocyte stimulating hormone (a-MSH) with potential photoprotective activity. Mimicking the action of a-MSH, afamelanotide stimulates melanocytes to increase the production and release of melanin. Increased melanocyte melanin may protect against ultraviolet radiation (UVR)-initiated cellular DNA damage, oxidation of membrane proteins, and alterations in intracellular signaling processes in epidermal cells. Endogenously, a-MSH is released by skin cells in response to UVR exposure, stimulating melanocytes to produce and release melanin.

Label: Afamelanotide

NCI Thesaurus Code: C82655 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2607750  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Melanotan I
Msh, 4-nle-7-phe-alpha-

External Source Codes: 
CAS Registry Number 75921-69-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 636135
PDQ Open Trial Search ID 636135 (check for NCI PDQ open clinical trial info)
UMLS CUI C2607750

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C78H111N21O19
code C82655
Contributing_Source FDA
Legacy_Concept_Name Afamelanotide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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