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Version: 17.06d (Release date: 2017-06-26)
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Afamelanotide (Code C82655)

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Terms & Properties

Preferred Name: Afamelanotide

Definition: A synthetic peptide analogue of the naturally occurring alpha-melanocyte stimulating hormone (a-MSH) with potential photoprotective activity. Mimicking the action of a-MSH, afamelanotide stimulates melanocytes to increase the production and release of melanin. Increased melanocyte melanin may protect against ultraviolet radiation (UVR)-initiated cellular DNA damage, oxidation of membrane proteins, and alterations in intracellular signaling processes in epidermal cells. Endogenously, a-MSH is released by skin cells in response to UVR exposure, stimulating melanocytes to produce and release melanin.

Label: Afamelanotide

NCI Thesaurus Code: C82655 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2607750  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AFAMELANOTIDE
Afamelanotide
CUV1647
Melanotan I
Msh, 4-nle-7-phe-alpha-
N-Acetyl-L-serinyl-L-tyrosyl-L-seryl-(2S)-2-aminohexanoyl-L-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanylglycyl-L-lysyl-L-prolyl-L-valinamide

External Source Codes: 
CAS Registry Number 75921-69-6 (see NLM ChemIDplus info)
FDA UNII Code QW68W3J66U
PDQ Closed Trial Search ID 636135
PDQ Open Trial Search ID 636135 (check for NCI PDQ open clinical trial info)
UMLS CUI C2607750

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C78H111N21O19
code C82655
Contributing_Source FDA
Legacy_Concept_Name Afamelanotide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82655

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