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Version: 17.06d (Release date: 2017-06-26)
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Botulinum Toxin Type A (Code C82623)

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Terms & Properties

Preferred Name: Botulinum Toxin Type A

Definition: An injectable formulation of a neurotoxin derived through the fermentation of the Hall strain of Clostridium botulinum type A with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of botulinum toxin type A (BTX-A) binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein SNAP-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding of ACH to motor end-plate nicotinic acid receptors and ACh-mediated muscle contraction are thus blocked. In addition to ACh, BTX-A may inhibit the release of neuropeptides, such as substance P and glutamate, which may contribute to its analgesic activity.

NCI-GLOSS Definition: A toxin made by the bacterium Clostridium botulinum. It can cause food poisoning. The drug Botox is a form of the toxin that can be used in small amounts to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. Botulinum toxin type A is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions.

NCI-GLOSS Definition: A drug used to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. OnabotulinumtoxinA is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions. It is a form of a toxin made by the bacterium Clostridium botulinum..

Display Name: Botulinum Toxin Type A

Label: Botulinum Toxin Type A

NCI Thesaurus Code: C82623 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0006050  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AbobotulinumtoxinA
Botox
Botox Cosmetic
Botulinum A Toxin
Botulinum Neurotoxin Type A
Botulinum Toxin A
botulinum toxin A
Botulinum Toxin Type A
BOTULINUM TOXIN TYPE A
BTX-A
Dysport
EvabotulinumtoxinA
IncobotulinumtoxinA
OnabotulinumtoxinA
onabotulinumtoxinA
Onaclostox
Xeomin

External Source Codes: 
CAS Registry Number 93384-43-1 (see NLM ChemIDplus info)
FDA UNII Code E211KPY694
PDQ Closed Trial Search ID 634923
PDQ Open Trial Search ID 634923 (check for NCI PDQ open clinical trial info)
UMLS CUI C0006050

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Treatment of cervical dystonia, severe primary axillary hyperhidrosis, Glabellar lines, blepharospasm, strabismus
code C82623
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Botulinum_Toxin_Type_A
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82623

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