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Version: 16.11d (Release date: 2016-11-28)
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Trastuzumab Emtansine (Code C82492)

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Terms & Properties

Preferred Name: Trastuzumab Emtansine

Definition: An antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers.

Display Name: Trastuzumab Emtansine

Label: Trastuzumab Emtansine

NCI Thesaurus Code: C82492 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2935436  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ado Trastuzumab Emtansine
Immunoglobulin G1, Anti-(Human p185neu Receptor) (Human-Mouse Monoclonal RhuMab HER2 Gamma1-Chain), Disulfide with Human-Mouse Monoclonal RhuMab HER2 Light Chain, Dimer, Tetraamide with N2'-(3-((1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)thio)-1-oxopropyl)-N2'-deacetylMaytansine
Kadcyla
PRO132365
RO5304020
T-DM1
Trastuzumab-DM1
Trastuzumab-MCC-DM1
Trastuzumab-MCC-DM1 Antibody-Drug Conjugate
Trastuzumab-MCC-DM1 Immunoconjugate
Trastuzumab Emtansine
TRASTUZUMAB EMTANSINE

External Source Codes: 
CAS Registry Number 1018448-65-1 (see NLM ChemIDplus info)
FDA UNII Code SE2KH7T06F
PDQ Closed Trial Search ID 564399
PDQ Open Trial Search ID 564399 (check for NCI PDQ open clinical trial info)
UMLS CUI C2935436

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C47H63ClN5O13S
code C82492
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Trastuzumab-MCC-DM1_Conjugate
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82492

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