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Version: 17.06d (Release date: 2017-06-26)
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HLA-A*2402-Restricted URLC10 Peptides Vaccine (Code C82421)

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Terms & Properties

Preferred Name: HLA-A*2402-Restricted URLC10 Peptides Vaccine

Definition: A cancer vaccine containing HLA-A*2402-restricted epitope peptides URLC10 (up-regulated lung cancer 10) with potential immunostimulatory and antineoplastic activities. Upon administration, HLA-A*2402-restricted URLC10 peptides vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against URLC10-expressing tumor cells. URLC10, a tumor associated antigen, is often overexpressed in lung, esophageal and gastric cancers. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity.

Label: HLA-A*2402-Restricted URLC10 Peptides Vaccine

NCI Thesaurus Code: C82421 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408683  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HLA-A*2402-Restricted URLC10 Peptides Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 637762
PDQ Open Trial Search ID 637762 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408683

Other Properties:
     Name Value (qualifiers indented underneath)
code C82421
Legacy_Concept_Name HLA-A_2402-Restricted_URLC10_Peptides_Vaccine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82421

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