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Version: 16.10e (Release date: 2016-10-31)
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P53-Synthetic Long Peptides Vaccine (Code C82420)

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Terms & Properties

Preferred Name: P53-Synthetic Long Peptides Vaccine

Definition: A peptide vaccine consisting of 10 synthetic long peptides (SLPs), 25-30 amino acids in size and derived from the middle portion of p53 (amino acids 70-251), mixed with the adjuvant Montanide ISA-51 with potential immunostimulatory and antitumor activities. Upon administration, p53 synthetic long peptide (70-251) vaccine may stimulate the host immune system to mount a cytotoxic T-cell lymphocyte (CTL) response against p53-expressing tumor cells. p53, a tumor associated antigen (TAA), may be overexpressed in variety of cancer cell types.

Label: P53-Synthetic Long Peptides Vaccine

NCI Thesaurus Code: C82420 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408682  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
P53-SLP (70-251) Vaccine
P53-Synthetic Long Peptides (70-251) Vaccine
P53-Synthetic Long Peptides Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 637782
PDQ Open Trial Search ID 637782 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408682

Other Properties:
Name Value (qualifiers indented underneath)
code C82420
Legacy_Concept_Name P53-Synthetic_Long_Peptides_70-251_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82420

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