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Version: 16.11d (Release date: 2016-11-28)
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CDC7 Kinase Inhibitor BMS-863233 (Code C82418)

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Terms & Properties

Preferred Name: CDC7 Kinase Inhibitor BMS-863233

Definition: An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.

Display Name: CDC7 Kinase Inhibitor BMS-863233

Label: CDC7 Kinase Inhibitor BMS-863233

NCI Thesaurus Code: C82418 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408681  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-863233
CDC7 Kinase Inhibitor BMS-863233
Cell Division Cycle 7 Homolog Kinase Inhibitor BMS-863233

External Source Codes: 
PDQ Closed Trial Search ID 637599
PDQ Open Trial Search ID 637599 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408681

Other Properties:
Name Value (qualifiers indented underneath)
code C82418
Contributing_Source CTRP
Legacy_Concept_Name CDC7_Kinase_Inhibitor_BMS-863233
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82418

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