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Version: 17.06d (Release date: 2017-06-26)
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Actinium Ac 225 Lintuzumab (Code C82414)

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Terms & Properties

Preferred Name: Actinium Ac 225 Lintuzumab

Definition: A radioimmunoconjugate consisting of the humanized monoclonal antibody lintuzumab conjugated to the alpha-emitting radioisotope actinium Ac 225 with potential antineoplastic activity. The monoclonal antibody moiety of actinium Ac 225 lintuzumab specifically binds to the cell surface antigen CD33 antigen, delivering a cytotoxic dose of alpha radiation to cells expressing CD33. CD33 is a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on myeloid leukemia cells.

Label: Actinium Ac 225 Lintuzumab

NCI Thesaurus Code: C82414 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL408677  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
225Ac-HuM195
Actinium-225-Labeled Humanized Anti-CD33 Monoclonal Antibody HuM195
Actinium Ac 225 Lintuzumab

External Source Codes: 
PDQ Closed Trial Search ID 637163
PDQ Open Trial Search ID 637163 (check for NCI PDQ open clinical trial info)
NCI META CUI CL408677

Other Properties:
     Name Value (qualifiers indented underneath)
code C82414
Legacy_Concept_Name Actinium_Ac_225_Lintuzumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82414

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