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Version: 17.06d (Release date: 2017-06-26)
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Rimiducid (Code C82412)

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Terms & Properties

Preferred Name: Rimiducid

Definition: A lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. This agent is used to homodimerize the Fv-containing drug-binding domains of genetically engineered receptors such as the iCD40 receptor of the autologous dendritic cell vaccine BP-GMAX-CD1, resulting in receptor activation.

Display Name: Rimiducid

Label: Rimiducid

NCI Thesaurus Code: C82412 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0965498  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Piperidinecarboxylic acid, 1-(1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl)-, 1,2-Ethanediylbis(imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene(3-(3,4-dimethoxyphenyl)propylidene)) Ester, (2S-(1(R*),2R*(S*(S*(1(R*),2R*)))))-
AP-1903
AP1903
Rimiducid
RIMIDUCID

External Source Codes: 
CAS Registry Number 195514-63-7 (see NLM ChemIDplus info)
FDA UNII Code H564L1W5J2
PDQ Closed Trial Search ID 640440
PDQ Open Trial Search ID 640440 (check for NCI PDQ open clinical trial info)
UMLS CUI C0965498

Other Properties:
     Name Value (qualifiers indented underneath)
code C82412
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tacrolimus_Analogue_AP1903
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C82412

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